MovDisordV3, Main, Exploration, bibRecord, 001661

Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome

Identifieur interne : 001661 ( Main/Exploration ); précédent : 001660; suivant : 001662

Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome

Auteurs : Qinbo Yang [République populaire de Chine, États-Unis] ; Lin Li [États-Unis] ; Rong Yang [République populaire de Chine, États-Unis] ; Gong-Qing Shen [États-Unis] ; Qiuyun Chen [États-Unis] ; Nancy Foldvary-Schaefer [États-Unis] ; William G. Ondo [États-Unis] ; Qing Kenneth Wang [République populaire de Chine, États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-02-15.

RBID : ISTEX:BC387641AC79678CC00FD0D92EBFA5EBFBF9452B

English descriptors

KwdEn :
- Chi-Square Distribution, Chromosomes, Human, Pair 9 (genetics), Cohort Studies, Community Health Planning, Family Health, Female, Gene Frequency, Genetic Predisposition to Disease (genetics), Genome-Wide Association Study, Genotype, Humans, Male, PTPRD gene, Polymorphism, Single Nucleotide (genetics), Receptor-Like Protein Tyrosine Phosphatases, Class 2 (genetics), Restless Legs Syndrome (epidemiology), Restless Legs Syndrome (genetics), Risk Factors, case‐control association study, family‐based association study, restless legs syndrome, sibling transmission/disequilibrium test.
MESH :
- chemical , genetics : Receptor-Like Protein Tyrosine Phosphatases, Class 2.
- epidemiology : Restless Legs Syndrome.
- genetics : Chromosomes, Human, Pair 9, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Restless Legs Syndrome.
- Chi-Square Distribution, Cohort Studies, Community Health Planning, Family Health, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, Male, Risk Factors.

Abstract

Objective:: We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22‐24 (RLS3) and a later genome‐wide association study (GWAS) implicated the PTPRD gene at the RLS3 locus as a susceptibility gene for RLS. However, from the standpoint of genetics, the GWAS association needs to be validated by independent studies. In this study, we used both family‐based and population‐based association studies to assess the association between PTPRD and RLS in an American Caucasian population. Methods:: We genotyped two intronic SNPs rs1975197 and rs4626664 in PTPRD in 144 family members from 15 families and a case control cohort of 189 patients and 560 controls. Direct DNA sequence analysis was used to screen coding exons and exon‐intron boundaries of PTPRD for rare mutations. Results:: A family‐based sibling transmission disequilibrium test showed association of RLS with SNP rs1975197 (P = 0.015), but not with rs4626664 (P = 0.622). The association with rs1975197 was significantly replicated by a population‐based case control association study (allelic P = 0.0004, odds ratio = 1.68; genotypic P = 0.0013 and 0.0003 for an additive and dominant model, respectively). One rare p.E1639D variant was identified in exon 39 in kindred RLS40005. The rare D1639 allele did not co‐segregate with RLS in the family, suggesting that p.E1639D variant is not a causative mutation. Conclusions:: This represents the first independent study to validate the association between PTPRD variants and RLS. Both family‐based and population‐based association studies suggest that PTPRD variant rs1975197 confers risk of RLS. © 2011 Movement Disorder Society

Url:

DOI: 10.1002/mds.23459

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome</title>
<author><name sortKey="Yang, Qinbo" sort="Yang, Qinbo" uniqKey="Yang Q" first="Qinbo" last="Yang">Qinbo Yang</name>
</author>
<author><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
</author>
<author><name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name>
</author>
<author><name sortKey="Shen, Gong Ing" sort="Shen, Gong Ing" uniqKey="Shen G" first="Gong-Qing" last="Shen">Gong-Qing Shen</name>
</author>
<author><name sortKey="Chen, Qiuyun" sort="Chen, Qiuyun" uniqKey="Chen Q" first="Qiuyun" last="Chen">Qiuyun Chen</name>
</author>
<author><name sortKey="Foldvary Chaefer, Nancy" sort="Foldvary Chaefer, Nancy" uniqKey="Foldvary Chaefer N" first="Nancy" last="Foldvary-Schaefer">Nancy Foldvary-Schaefer</name>
</author>
<author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name>
</author>
<author><name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:BC387641AC79678CC00FD0D92EBFA5EBFBF9452B</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23459</idno>
<idno type="url">https://api.istex.fr/document/BC387641AC79678CC00FD0D92EBFA5EBFBF9452B/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001A39</idno>
<idno type="wicri:Area/Istex/Curation">001A39</idno>
<idno type="wicri:Area/Istex/Checkpoint">000394</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Yang Q:family:based:and</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895410</idno>
<idno type="RBID">PMC:3895410</idno>
<idno type="wicri:Area/Pmc/Corpus">000228</idno>
<idno type="wicri:Area/Pmc/Curation">000228</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000267</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001476</idno>
<idno type="wicri:Area/PubMed/Curation">001476</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001340</idno>
<idno type="wicri:Area/Ncbi/Merge">002F44</idno>
<idno type="wicri:Area/Ncbi/Curation">002F44</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002F44</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Yang Q:family:based:and</idno>
<idno type="wicri:Area/Main/Merge">001715</idno>
<idno type="wicri:Area/Main/Curation">001661</idno>
<idno type="wicri:Area/Main/Exploration">001661</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome</title>
<author><name sortKey="Yang, Qinbo" sort="Yang, Qinbo" uniqKey="Yang Q" first="Qinbo" last="Yang">Qinbo Yang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shen, Gong Ing" sort="Shen, Gong Ing" uniqKey="Shen G" first="Gong-Qing" last="Shen">Gong-Qing Shen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Qiuyun" sort="Chen, Qiuyun" uniqKey="Chen Q" first="Qiuyun" last="Chen">Qiuyun Chen</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foldvary Chaefer, Nancy" sort="Foldvary Chaefer, Nancy" uniqKey="Foldvary Chaefer N" first="Nancy" last="Foldvary-Schaefer">Nancy Foldvary-Schaefer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Sleep Medicine, Neurological Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>William G. Ondo, Department of Neurology, Baylor College of Medicine, Houston, TXQing Kenneth Wang, Center for Cardiovascular Genetics/NE40, Cleveland Clinic, 9500 Euclid Ave, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Cardiology, Center for Cardiovascular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Medicine, CCLCM of Case Western Reserve University, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Sleep Medicine, Neurological Institute, Cleveland Clinic, Cleveland, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>William G. Ondo, Department of Neurology, Baylor College of Medicine, Houston, TXQing Kenneth Wang, Center for Cardiovascular Genetics/NE40, Cleveland Clinic, 9500 Euclid Ave, Cleveland</wicri:cityArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-02-15">2011-02-15</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="516">516</biblScope>
<biblScope unit="page" to="519">519</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">BC387641AC79678CC00FD0D92EBFA5EBFBF9452B</idno>
<idno type="DOI">10.1002/mds.23459</idno>
<idno type="ArticleID">MDS23459</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chi-Square Distribution</term>
<term>Chromosomes, Human, Pair 9 (genetics)</term>
<term>Cohort Studies</term>
<term>Community Health Planning</term>
<term>Family Health</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>PTPRD gene</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Receptor-Like Protein Tyrosine Phosphatases, Class 2 (genetics)</term>
<term>Restless Legs Syndrome (epidemiology)</term>
<term>Restless Legs Syndrome (genetics)</term>
<term>Risk Factors</term>
<term>case‐control association study</term>
<term>family‐based association study</term>
<term>restless legs syndrome</term>
<term>sibling transmission/disequilibrium test</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor-Like Protein Tyrosine Phosphatases, Class 2</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 9</term>
<term>Genetic Predisposition to Disease</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Restless Legs Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chi-Square Distribution</term>
<term>Cohort Studies</term>
<term>Community Health Planning</term>
<term>Family Health</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Risk Factors</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective:: We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22‐24 (RLS3) and a later genome‐wide association study (GWAS) implicated the PTPRD gene at the RLS3 locus as a susceptibility gene for RLS. However, from the standpoint of genetics, the GWAS association needs to be validated by independent studies. In this study, we used both family‐based and population‐based association studies to assess the association between PTPRD and RLS in an American Caucasian population. Methods:: We genotyped two intronic SNPs rs1975197 and rs4626664 in PTPRD in 144 family members from 15 families and a case control cohort of 189 patients and 560 controls. Direct DNA sequence analysis was used to screen coding exons and exon‐intron boundaries of PTPRD for rare mutations. Results:: A family‐based sibling transmission disequilibrium test showed association of RLS with SNP rs1975197 (P = 0.015), but not with rs4626664 (P = 0.622). The association with rs1975197 was significantly replicated by a population‐based case control association study (allelic P = 0.0004, odds ratio = 1.68; genotypic P = 0.0013 and 0.0003 for an additive and dominant model, respectively). One rare p.E1639D variant was identified in exon 39 in kindred RLS40005. The rare D1639 allele did not co‐segregate with RLS in the family, suggesting that p.E1639D variant is not a causative mutation. Conclusions:: This represents the first independent study to validate the association between PTPRD variants and RLS. Both family‐based and population‐based association studies suggest that PTPRD variant rs1975197 confers risk of RLS. © 2011 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Ohio</li>
<li>Texas</li>
</region>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Qinbo" sort="Yang, Qinbo" uniqKey="Yang Q" first="Qinbo" last="Yang">Qinbo Yang</name>
</noRegion>
<name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name>
</country>
<country name="États-Unis"><region name="Ohio"><name sortKey="Yang, Qinbo" sort="Yang, Qinbo" uniqKey="Yang Q" first="Qinbo" last="Yang">Qinbo Yang</name>
</region>
<name sortKey="Chen, Qiuyun" sort="Chen, Qiuyun" uniqKey="Chen Q" first="Qiuyun" last="Chen">Qiuyun Chen</name>
<name sortKey="Chen, Qiuyun" sort="Chen, Qiuyun" uniqKey="Chen Q" first="Qiuyun" last="Chen">Qiuyun Chen</name>
<name sortKey="Foldvary Chaefer, Nancy" sort="Foldvary Chaefer, Nancy" uniqKey="Foldvary Chaefer N" first="Nancy" last="Foldvary-Schaefer">Nancy Foldvary-Schaefer</name>
<name sortKey="Foldvary Chaefer, Nancy" sort="Foldvary Chaefer, Nancy" uniqKey="Foldvary Chaefer N" first="Nancy" last="Foldvary-Schaefer">Nancy Foldvary-Schaefer</name>
<name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
<name sortKey="Li, Lin" sort="Li, Lin" uniqKey="Li L" first="Lin" last="Li">Lin Li</name>
<name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name>
<name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G." last="Ondo">William G. Ondo</name>
<name sortKey="Shen, Gong Ing" sort="Shen, Gong Ing" uniqKey="Shen G" first="Gong-Qing" last="Shen">Gong-Qing Shen</name>
<name sortKey="Shen, Gong Ing" sort="Shen, Gong Ing" uniqKey="Shen G" first="Gong-Qing" last="Shen">Gong-Qing Shen</name>
<name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<name sortKey="Wang, Qing Kenneth" sort="Wang, Qing Kenneth" uniqKey="Wang Q" first="Qing Kenneth" last="Wang">Qing Kenneth Wang</name>
<name sortKey="Yang, Qinbo" sort="Yang, Qinbo" uniqKey="Yang Q" first="Qinbo" last="Yang">Qinbo Yang</name>
<name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name>
<name sortKey="Yang, Rong" sort="Yang, Rong" uniqKey="Yang R" first="Rong" last="Yang">Rong Yang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001661 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001661 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:BC387641AC79678CC00FD0D92EBFA5EBFBF9452B
   |texte=   Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome

Family‐based and population‐based association studies validate PTPRD as a risk factor for restless legs syndrome

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.